Anett Kontaveit defeated Angelique Kerber in the second round on Wednesday as the Italian Open lost both its top seeds, with men’s No. 1 Andy Murray falling to Fabio Fognini on Tuesday.
Also on Tuesday, Maria Sharapova retired from her second-round match against Mirjana Lucic-Baroni, just hours after she was denied a wild card for Roland Garros.
Defeat meant the 30-year-old also missed out on a chance to make the main draw at Wimbledon, which she could have achieved by reaching the semifinals here.
Men: Second round: Alexander Zverev bt Viktor Troicki 6-3, 6-4; Rafael Nadal bt Nicolas Almagro 3-0 retired; Kei Nishikori bt David Ferrer 7-5, 6-2; Juan-Martin del Potro bt Kyle Edmund 7-5, 6-4. Fabio Fognini bt Andy Murray 6-2, 6-4; Novak Djokovic bt Aljaz Bedene 7-6(2), 6-2.
Women: Second round: Anett Kontaveit bt Angelique Kerber 6-4, 6-0; Simona Halep bt Laura Sigemund 6-4, 6-4; Mirjana Lucic bt Maria Sharapova 6-4, 3-6, 1-2 retired; Svetlana Kuznetsova bt Katerina Siniakova 6-1, 7-6(3).